Topical Pain Relief: Creams, Gels, and Rubs (2024)

When your joints are painful or your muscles ache, topical painkillers -- those you apply to your skin -- may offer relief. You'll find many products for topical pain relief at your local drugstore. Others can be prescribed by your doctor.

Here are some popular options and what you need to know if you'd like to give them a try.

Analgesic Creams, Rubs, and Sprays

Topical painkillers, or analgesics, are sprayed on, rubbed in, or applied as patches onto the skin over painful muscles or joints. Although all are designed to relieve pain, different products use different ingredients. Here are some of the most common.

  • Counterirritants. Ingredients such as menthol, methyl salicylate (oil of evergreen), and camphor are called counterirritants because they create a burning or cooling sensation that distracts your mind from the pain.
  • Salicylates. These same ingredients that give aspirin its pain-relieving quality are found in some creams. When absorbed into the skin, they may help with pain, particularly in joints close to the skin, such as the fingers, knees, and elbows.
  • Prescription NSAIDs. Topical forms of nonsteroidal anti-inflammatory drugs have fewer of the typical NSAID side effects, like stomach upset and bleeding. Don’t use them if you’re also taking oral NSAIDs.
  • Capsaicin. The main ingredient of hot chili peppers, capsaicin is also one of the most effective ingredients for topical pain relief. It can be helpful for joint pain and for diabetic nerve pain. When first applied, capsaicin creams cause a warm tingling or burning sensation. This gets better over time. You may need to apply these creams for a few days up to a couple of weeks before you notice relief from pain.
  • Lidocaine. This medicine numbs pain. It comes as a gel or a patch that you apply to the painful area. Talk to your doctor first if you have liver problems or take heart rhythm drugs.

Here's what you need to know to get the greatest effects and minimize the risks of these products:

  • Read the package insert and follow directions carefully. If there is an insert, save it to refer to later.
  • Never apply them to wounds or damaged skin.
  • Do not use them along with a heating pad because it could cause burns.
  • Do not use them under a tight bandage.
  • Wash your hands well after using them, or wear gloves. Avoid touching your eyes and genitals with the product on your hands.
  • If you are allergic to aspirin or are taking blood thinners, check with your doctor before using topical medications that contain salicylates.

Hot Packs and Cold Packs

Hot or cold packs -- or sometimes a combination of the two -- can provide relief for sore muscles and joints.

Cold numbs sore areas. It is especially helpful for the pain and swelling of an arthritis flare or joint injury, such as a sprained ankle. Cold may reduce inflammation by constricting blood flow to the injured area.

You can apply cold using a commercial cold pack or with a water bottle filled with ice and cold water.

You can also use items already in your home such as:

  • Zippable plastic freezer or storage bags filled with ice and water
  • A washcloth or hand towel dipped into cold water and ice
  • A bag of frozen vegetables, such as peas or corn

Heat packs relax your muscles. Heat dilates blood vessels, sending more oxygen and blood to the area. Heat also decreases the sensation of pain.

You can apply heat with commercial heat packs, heating pads, or hot water bottles. Other ways to use heat include:

  • Soaking in a hot bathtub
  • Standing under a hot shower
  • Soaking a washcloth or hand towel in warm water then applying to painful joints or muscles

To get the most relief from hot or cold without damaging your skin, try these tips:

  • Use either heat or cold for only 15-20 minutes at a time.
  • Place a towel between your skin and the cold or heat source.
  • Don't use heat or cold on skin with open cuts or sores.
  • Don't use cold packs if you have vasculitis or poor circulation.
  • Test the temperature before using heat or cold.
  • Do not use creams, heat rubs, or lotions on your skin while using a hot or cold treatment.
  • Be especially careful with heating pads, which can cause severe burns if too hot or if left on for too long.
  • Do not make your bath or shower water too hot. This may cause dizziness or fatigue.
Topical Pain Relief: Creams, Gels, and Rubs (2024)

FAQs

What is topical pain relief cream? ›

A topical analgesic is a medicine that's applied to the skin to relieve pain in your muscles and joints alike. Unlike other pain relievers like acetaminophen, they should not be taken by mouth (orally).

What is the most effective pain relief gel? ›

Biofreeze Professional Pain Relief Gel is the best overall muscle pain relief cream due to its fast-acting and long-lasting formula. Its cooling menthol and camphor provide immediate relief by interfering with the body's pain signals, making it an ideal choice for quickly alleviating muscle soreness and discomfort.

Do topical pain creams enter the bloodstream? ›

Local effects occur when the drug is applied and absorbed into the skin at the site of pain (Leppert et al., 2018). Systemic effects occur when a drug is absorbed through the skin and accesses the blood stream for distribution throughout the body by the systemic circulation.

What is the strongest natural painkiller? ›

Endorphins are the body's natural painkillers. Released by the hypothalamus and pituitary gland in response to pain or stress, this group of peptide hormones both relieves pain and creates a general feeling of well-being.

What is the No 1 for pain relief? ›

Acetaminophen. Acetaminophen is usually recommended as a first line treatment for mild to moderate pain. It might be taken for pain due to a skin injury, headache, or conditions that affect the muscles and bones.

What is the most powerful pain relief? ›

The most powerful pain relievers are opioids.

Is gel or cream better for pain relief? ›

Formula – The formulation is crucial for skin penetration. Without getting into too much detail, gel is more effective than cream. Blood Flow – If blood flow to the area is increased due to exercise, a heat pack, a hot shower, massage, etc there is a better chance of the medication being absorbed.

What must you never use to apply a topical medication? ›

Never use your bare fingers to apply ointments, lotions or liniments. Do not discard gloves and supplies in areas accessible to clients. Directions for application of the medication should be a part of the physician's order or included with the instructions accompanying the medication.

What are the disadvantages of topical creams? ›

Disadvantages of topical formulations include:
  • They can be time-consuming to apply.
  • At times, the regimen can be complicated, especially if several different formulations have been prescribed.
  • The applications may also be messy or uncomfortable.

Why was Voltaren taken off the market? ›

World's Most Popular Painkiller Raises Heart Attack Risk : Shots - Health News Diclofenac — sold under the brand names Voltaren, Cambia, Cataflam and Zipsor — raises the risk of a heart attack by about 40 percent. But that hasn't prevented the drug from becoming the world's most popular painkiller in its class.

What is the number one painkiller for arthritis? ›

NSAIDs are the most effective oral medicines for OA. They include ibuprofen (Motrin, Advil) naproxen (Aleve) and diclofenac (Voltaren, others). All work by blocking enzymes that cause pain and swelling. The problem is that some of those enzymes also help blood to clot and protect the lining of your stomach.

What are the examples of topical anti-inflammatory cream? ›

List of Topical non-steroidal anti-inflammatories
Drug NameReviews
Voltaren Arthritis Pain Gel (Pro) Generic name: diclofenac257 reviews
Flector Patch (Pro) Generic name: diclofenac85 reviews
Pennsaid (Pro) Generic name: diclofenac53 reviews
Solaraze (Pro) Generic name: diclofenac4 reviews
25 more rows

Which is better, Voltaren or Penetrex? ›

Penetrex goes on and [penetrates] better than Voltaren,” she said. And not only does it absorb faster, but it lasts much longer, too.

What is topical cream What is it used for? ›

Applying medication to the skin or mucous membranes allows it to enter the body from there. Medication applied in this way is known as topical medication. It can also be used to treat pain or other problems in specific parts of the body.

What topical painkillers are good for nerve pain? ›

Some over-the-counter (OTC) topical creams, like lidocaine or capsaicin, may be helpful for nerve pain. Nerve pain is distinct from typical tissue pain. When you have tissue pain, like falling down or getting a cut, your nerves deliver the pain message to your brain.

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